Projekte
Cancer cells undergo oncogene-directed reprogramming in order to meet the energetic and biosynthetic challenges of cell survival, growth and proliferation. Our lab aims at identifying vulnerabilities of cancer cells in order to reveal targets for the development of innovative therapeutic strategies. In particular, we focus on the signaling and lipid metabolic alterations in KRAS-induced lung and pancreatic cancer. We work on cell lines (using a combination of techniques in molecular biology, cell biology and biochemistry), mouse models of lung and pancreatic cancer and human specimens. Our Institute and our collaborator institutions provide state-of-the-art technologies which allow us to develop novel approaches to treat cancer.
